Long‐duration response to levodopa influences the pharmacodynamics of short‐duration response in Parkinson's disease
Identifieur interne : 002015 ( Main/Exploration ); précédent : 002014; suivant : 002016Long‐duration response to levodopa influences the pharmacodynamics of short‐duration response in Parkinson's disease
Auteurs : Mario Zappia ; Rosanna Colao ; Rita Montesanti ; Milena Rizzo ; Umberto Aguglia ; Antonio Gambardella ; Rosario L No Oliveri ; Aldo Quattrone [Italie]Source :
- Annals of Neurology [ 0364-5134 ] ; 1997-08.
Abstract
The long duration response (LDR) to chronic levodopa treatment may mask the short‐duration response (SDR) to a single dose of the drug in Parkinson's disease (PD). As a result, the measurement of SDR may be inaccurate for establishing levodopa dosing regimen in individual patients. To evaluate the possible contamination of SDR by LDR, we investigated in 16 patients with PD the characteristics of SDR to a single dose of levodopa administered after a prolonged washout from chronic therapy and after a 15‐day treatment period with levodopa. Levodopa treatment produced a sustained LDR, and the SDR, measured on the 15th day of treatment, had lower magnitude and shorter duration than the response recorded after washout. Moreover, after treatment, SDR did not vary between patients with mild and severe PD, whereas, after washout, severely affected patients had larger but shorter SDR than mildly affected patients. The evaluation of SDR without the interference of LDR is critical in defining the characteristics of the therapeutic response to levodopa.
Url:
DOI: 10.1002/ana.410420217
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Long‐duration response to levodopa influences the pharmacodynamics of short‐duration response in Parkinson's disease</title>
<author><name sortKey="Zappia, Mario" sort="Zappia, Mario" uniqKey="Zappia M" first="Mario" last="Zappia">Mario Zappia</name>
</author>
<author><name sortKey="Colao, Rosanna" sort="Colao, Rosanna" uniqKey="Colao R" first="Rosanna" last="Colao">Rosanna Colao</name>
</author>
<author><name sortKey="Montesanti, Rita" sort="Montesanti, Rita" uniqKey="Montesanti R" first="Rita" last="Montesanti">Rita Montesanti</name>
</author>
<author><name sortKey="Rizzo, Milena" sort="Rizzo, Milena" uniqKey="Rizzo M" first="Milena" last="Rizzo">Milena Rizzo</name>
</author>
<author><name sortKey="Aguglia, Umberto" sort="Aguglia, Umberto" uniqKey="Aguglia U" first="Umberto" last="Aguglia">Umberto Aguglia</name>
</author>
<author><name sortKey="Gambardella, Antonio" sort="Gambardella, Antonio" uniqKey="Gambardella A" first="Antonio" last="Gambardella">Antonio Gambardella</name>
</author>
<author><name sortKey="Oliveri, Rosario L No" sort="Oliveri, Rosario L No" uniqKey="Oliveri R" first="Rosario L No" last="Oliveri">Rosario L No Oliveri</name>
</author>
<author><name sortKey="Quattrone, Aldo" sort="Quattrone, Aldo" uniqKey="Quattrone A" first="Aldo" last="Quattrone">Aldo Quattrone</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">ISTEX</idno>
<idno type="RBID">ISTEX:A4DCDD3645624027A59D05C13D9AE43ACB8B8CE3</idno>
<date when="1997" year="1997">1997</date>
<idno type="doi">10.1002/ana.410420217</idno>
<idno type="url">https://api.istex.fr/document/A4DCDD3645624027A59D05C13D9AE43ACB8B8CE3/fulltext/pdf</idno>
<idno type="wicri:Area/Main/Corpus">002942</idno>
<idno type="wicri:Area/Main/Curation">002591</idno>
<idno type="wicri:Area/Main/Exploration">002015</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Long‐duration response to levodopa influences the pharmacodynamics of short‐duration response in Parkinson's disease</title>
<author><name sortKey="Zappia, Mario" sort="Zappia, Mario" uniqKey="Zappia M" first="Mario" last="Zappia">Mario Zappia</name>
<affiliation><wicri:noCountry code="subField">Catanzaro</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Colao, Rosanna" sort="Colao, Rosanna" uniqKey="Colao R" first="Rosanna" last="Colao">Rosanna Colao</name>
<affiliation><wicri:noCountry code="subField">Catanzaro</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Montesanti, Rita" sort="Montesanti, Rita" uniqKey="Montesanti R" first="Rita" last="Montesanti">Rita Montesanti</name>
<affiliation><wicri:noCountry code="subField">Catanzaro</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Rizzo, Milena" sort="Rizzo, Milena" uniqKey="Rizzo M" first="Milena" last="Rizzo">Milena Rizzo</name>
<affiliation><wicri:noCountry code="subField">Catanzaro</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Aguglia, Umberto" sort="Aguglia, Umberto" uniqKey="Aguglia U" first="Umberto" last="Aguglia">Umberto Aguglia</name>
<affiliation><wicri:noCountry code="subField">Catanzaro</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Gambardella, Antonio" sort="Gambardella, Antonio" uniqKey="Gambardella A" first="Antonio" last="Gambardella">Antonio Gambardella</name>
<affiliation><wicri:noCountry code="subField">Catanzaro</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Oliveri, Rosario L No" sort="Oliveri, Rosario L No" uniqKey="Oliveri R" first="Rosario L No" last="Oliveri">Rosario L No Oliveri</name>
<affiliation><wicri:noCountry code="subField">Catanzaro</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Quattrone, Aldo" sort="Quattrone, Aldo" uniqKey="Quattrone A" first="Aldo" last="Quattrone">Aldo Quattrone</name>
<affiliation><wicri:noCountry code="subField">Catanzaro</wicri:noCountry>
</affiliation>
<affiliation wicri:level="1"><country xml:lang="fr">Italie</country>
<wicri:regionArea>Institute of Experimental Medicine and Biotechnology, National Research Council, Piano Lago di Mangone (Cosenza)</wicri:regionArea>
<wicri:noRegion>Piano Lago di Mangone (Cosenza)</wicri:noRegion>
</affiliation>
</author>
</analytic>
<monogr></monogr>
<series><title level="j">Annals of Neurology</title>
<title level="j" type="sub">Official Journal of the American Neurological Association and the Child Neurology Society</title>
<title level="j" type="abbrev">Ann Neurol.</title>
<idno type="ISSN">0364-5134</idno>
<idno type="eISSN">1531-8249</idno>
<imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher>
<pubPlace>Hoboken</pubPlace>
<date type="published" when="1997-08">1997-08</date>
<biblScope unit="volume">42</biblScope>
<biblScope unit="issue">2</biblScope>
<biblScope unit="page" from="245">245</biblScope>
<biblScope unit="page" to="248">248</biblScope>
</imprint>
<idno type="ISSN">0364-5134</idno>
</series>
<idno type="istex">A4DCDD3645624027A59D05C13D9AE43ACB8B8CE3</idno>
<idno type="DOI">10.1002/ana.410420217</idno>
<idno type="ArticleID">ANA410420217</idno>
</biblStruct>
</sourceDesc>
<seriesStmt><idno type="ISSN">0364-5134</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass></textClass>
<langUsage><language ident="en">en</language>
</langUsage>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">The long duration response (LDR) to chronic levodopa treatment may mask the short‐duration response (SDR) to a single dose of the drug in Parkinson's disease (PD). As a result, the measurement of SDR may be inaccurate for establishing levodopa dosing regimen in individual patients. To evaluate the possible contamination of SDR by LDR, we investigated in 16 patients with PD the characteristics of SDR to a single dose of levodopa administered after a prolonged washout from chronic therapy and after a 15‐day treatment period with levodopa. Levodopa treatment produced a sustained LDR, and the SDR, measured on the 15th day of treatment, had lower magnitude and shorter duration than the response recorded after washout. Moreover, after treatment, SDR did not vary between patients with mild and severe PD, whereas, after washout, severely affected patients had larger but shorter SDR than mildly affected patients. The evaluation of SDR without the interference of LDR is critical in defining the characteristics of the therapeutic response to levodopa.</div>
</front>
</TEI>
<affiliations><list><country><li>Italie</li>
</country>
</list>
<tree><noCountry><name sortKey="Aguglia, Umberto" sort="Aguglia, Umberto" uniqKey="Aguglia U" first="Umberto" last="Aguglia">Umberto Aguglia</name>
<name sortKey="Colao, Rosanna" sort="Colao, Rosanna" uniqKey="Colao R" first="Rosanna" last="Colao">Rosanna Colao</name>
<name sortKey="Gambardella, Antonio" sort="Gambardella, Antonio" uniqKey="Gambardella A" first="Antonio" last="Gambardella">Antonio Gambardella</name>
<name sortKey="Montesanti, Rita" sort="Montesanti, Rita" uniqKey="Montesanti R" first="Rita" last="Montesanti">Rita Montesanti</name>
<name sortKey="Oliveri, Rosario L No" sort="Oliveri, Rosario L No" uniqKey="Oliveri R" first="Rosario L No" last="Oliveri">Rosario L No Oliveri</name>
<name sortKey="Rizzo, Milena" sort="Rizzo, Milena" uniqKey="Rizzo M" first="Milena" last="Rizzo">Milena Rizzo</name>
<name sortKey="Zappia, Mario" sort="Zappia, Mario" uniqKey="Zappia M" first="Mario" last="Zappia">Mario Zappia</name>
</noCountry>
<country name="Italie"><noRegion><name sortKey="Quattrone, Aldo" sort="Quattrone, Aldo" uniqKey="Quattrone A" first="Aldo" last="Quattrone">Aldo Quattrone</name>
</noRegion>
</country>
</tree>
</affiliations>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/ParkinsonV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 002015 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 002015 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Sante |area= ParkinsonV1 |flux= Main |étape= Exploration |type= RBID |clé= ISTEX:A4DCDD3645624027A59D05C13D9AE43ACB8B8CE3 |texte= Long‐duration response to levodopa influences the pharmacodynamics of short‐duration response in Parkinson's disease }}
This area was generated with Dilib version V0.6.23. |